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Sep 16, 2025, 09:45 AM ETWeek 3 gets underway with a matchup of AFC East rivals when the Miami Dolphins visit the Buffalo Bills on “Thursday Night Football.”The Bills cruised past the New York Jets in Week 2 to move to 2-0, while the Dolphins dropped to 0-2 after falling to the Patriots in New England.Not surprisingly, the Bills are the biggest favorite (-13.5) on the Week 3 slate.Sunday afternoon features two matchups of undefeated teams, with the Philadelphia Eagles (-3.5) hosting the Los Angeles Rams and the Arizona Cardinals hitting the road to face the San Francisco 49ers (-1.5).”Sunday Night Football” will feature a pair of winless teams: the New York Giants and… the Kansas City Chiefs. The Giants fell to 0-2 after a wild finish in Dallas, and the Chiefs remained winless after a loss to the Eagles in their Super Bowl rematch.The week wraps up with an enticing “Monday Night Football” matchup, as the Detroit Lions visit the Baltimore Ravens at 8:15 p.m. ET on ABC/ESPN.Here’s a look at the odds for every Week 3 game.Odds as of publication time. For the most current odds, visit ESPN BET. Jump to:MIA-BUF | NYJ-TB | IND-TEN | LV-WSHLAR-PHI | ATL-CAR | HOU-JAX | GB-CLEPIT-NE | CIN-MIN | DEN-LAC | NO-SEAARI-SF | DAL-CHI | KC-NYG | DET-BAL Miami Dolphins vs. Buffalo Bills -12.5Thursday, 8:15 p.m., Prime VideoLine movement: Opened Bills -10.5Money Line: Dolphins (+550); Bills (-900)Total: 49.5; Opened: 48.5FPI favorite: Bills by 10.9 with a 75.27% probability to win the game outrightNew York Jets vs. Tampa Bay Buccaneers -6.5Sunday, 1 p.m., FOXMoney Line: Jets (+270); Buccaneers (-340)Total: 44.5; Opened: 44.5FPI favorite: Buccaneers by 8.4 with a 71.63% probability to win the game outrightIndianapolis Colts -3.5 vs. Tennessee TitansSunday, 1 p.m., CBSMoney Line: Colts (-190); Titans (+160)Total: 43.5; Opened: 43.5FPI favorite: Colts by 6.2 with a 65.13% probability to win the game outrightLas Vegas Raiders vs. Washington Commanders -3.5Sunday, 1 p.m., FOXLine movement: Opened Commanders -6.5Money Line: Raiders (+155); Commanders (-185)Total: 44.5; Opened: 47.5FPI favorite: Commanders by 3.5 with a 59.83% probability to win the game outrightLos Angeles Rams vs. Philadelphia Eagles -3.5Sunday, 1 p.m., FOXMoney Line: Rams (+160); Eagles (-190)Total: 44.5; Opened: 45.5FPI favorite: Eagles by 3.1 with a 58.6% probability to win the game outrightAtlanta Falcons -5.5 vs. Carolina PanthersSunday, 1 p.m., FOXLine movement: Opened Falcons -3.5Money Line: Falcons (-250); Panthers (+210)Total: 43.5; Opened: 44.5FPI favorite: Falcons by 2.4 with a 55.73% probability to win the game outrightHouston Texans vs. Jacksonville Jaguars -1.5Sunday, 1 p.m., CBSMoney Line: Texans (-105); Jaguars (-115)Total: 44.5; Opened: 43.5FPI favorite: Jaguars by 1.5 with a 53.4% probability to win the game outrightGreen Bay Packers -7.5 vs. Cleveland BrownsSunday, 1 p.m., FOXMoney Line: Packers (-450); Browns (+340)Total: 42.5; Opened: 43.5FPI favorite: Packers by 8.5 with a 70.8% probability to win the game outrightPittsburgh Steelers -1.5 vs. New England PatriotsSunday, 1 p.m., CBSMoney Line: Steelers (-125); Patriots (+105)Total: 44.5; Opened: 44.5FPI favorite: Patriots by 0 with a 49.93% probability to win the game outrightCincinnati Bengals vs. Minnesota Vikings -3.5Sunday, 1 p.m., CBSLine movement: Opened Vikings -5.5Money Line: Bengals (+135); Vikings (-155)Total: 42.5; Opened: 44.5FPI favorite: Vikings by 2.3 with a 56% probability to win the game outrightDenver Broncos vs. Los Angeles Chargers -2.5Sunday, 4:05 p.m., CBSMoney Line: Broncos (+135); Chargers (-155)Total: 45.5; Opened: 46.5FPI favorite: Chargers by 2.8 with a 57.27% probability to win the game outrightNew Orleans Saints vs. Seattle Seahawks -7.5Sunday, 4:05 p.m., CBSMoney Line: Saints (+300); Seahawks (-400)Total: 41.5; Opened: 42.5FPI favorite: Seahawks by 5.7 with a 64.73% probability to win the game outrightArizona Cardinals vs. San Francisco 49ers -1.5Sunday, 4:25 p.m., FOXLine movement: Opened Cardinals -1.5Money Line: Cardinals (+105); 49ers (-125)Total: 44.5; Opened: 43.5FPI favorite: Cardinals by 1 with a 52.6% probability to win the game outrightDallas Cowboys vs. Chicago Bears -1.5Sunday, 4:25 p.m., FOXMoney Line: Cowboys (-105); Bears (-115)Total: 49.5; Opened: 49.5FPI favorite: Cowboys by 1.4 with a 53.47% probability to win the game outrightKansas City Chiefs -6.5 vs. New York GiantsSunday, 8:20 p.m., NBCMoney Line: Chiefs (-275); Giants (+225)Total: 44.5; Opened: 42.5FPI favorite: Chiefs by 6.4 with a 65.4% probability to win the game outrightDetroit Lions vs. Baltimore Ravens -5.5Monday, 8:15 p.m., ABC, ESPNMoney Line: Lions (+220); Ravens (-270)Total: 51.5; Opened: 52.5FPI favorite: Ravens by 2.5 with a 56.67% probability to win the game outright
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